Fast Green FCF Chemical Properties

Melting point:

290 °C (dec.) (lit.)

Boiling point:

260℃[at 101 325 Pa]

Density 

0.513[at 20℃]

vapor pressure 

0Pa at 25℃

storage temp. 

room temp

solubility 

H2O: soluble50mg/mL, clear, colorless to faintly yellow

form 

Powder/Solid

Colour Index 

42053

color 

Red to Red-Brown

PH

2.7 (10g/l, H2O, 20℃)

Odor

Odorless

Water Solubility 

Soluble in water, glycerin, glycol and ethanol.

Sensitive 

Hygroscopic

λmax

532 nm

Decomposition 

290 °C

Merck 

14,3941

BRN 

5718212

Stability:

Stable. Incompatible with strong oxidizing agents.

Biological Applications

Drug delivery and tissue engineering; photodynamic therapy; dental materials; treating cancer,diabetes; wound dressing materials

LogP

-5.42 at 25℃

IARC

3 (Vol. 16, Sup 7) 1987

EPA Substance Registry System

C.I. Food Green 3, disodium salt (2353-45-9)

Safety Information

Hazard Codes 

Xn

Risk Statements 

68-40-20/21/22

Safety Statements 

22-24/25-37/39-25-36/37

WGK Germany 

3

RTECS 

BQ4425000

F 

3

TSCA 

Yes

HS Code 

32041900

Hazardous Substances Data

2353-45-9(Hazardous Substances Data)

Toxicity

LD50 orally in rats: >2 g/kg (Lu, Lavalle)

MSDS

• Language:English Provider:N-Ethyl-N-[4-[[4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl](4-hydroxy-2-sulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-3-sulfo-benzenemethanaminium hydroxide inner salt disodium salt
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Fast Green FCF Usage And Synthesis

Description

FD & C Green No. 3 is principally the inner salt disodium salt of N-ethyl-N-[4-[[4-[ethyl[(3-sulfophenyl)methyl] amino]phe- nyl](4-hydroxy-2-sulfophenyl)methylene]-2,5-cyclohexadien- 1 -ylidene]-3-sulfobenzenemethanaminium hydroxide.
The colorant is a red to brown-violet powder or collection of crystals that dissolves in water to give a solution blue-green at neutrality, green in acid, and blue-violet in base. When dissolved in concentrated sulfuric acid, it yields a brown-orange solution that turns green when diluted with water. When heated to 130° with glycerine triacetate and an excess of acetic anhydride, acety- lation of its phenolic hydroxyl group causes a color change from green to light blue.
Fast Green FCF is regularly used in beverages, desserts (puddings, ice cream, sherbet), candy, bakery goods, dairy products, and maraschino cherries. The color is also used in pharmaceuticals, cosmetics and histological stains.1 .

Chemical Properties

green powder

Uses

Stain for showing collagen, muscle, cytoplasm and cells in mammalian tissuesFast Green FCF is used as a quantitative stain for histones and protein stain in electrophoresis. It is also used as a food dye, which is poorly absorbed by intestine. It is used for tinned green peas and other vegetables, jellies, sauces, fish and desserts. It is considered as a replacement of Light Green SF yellowish in Masson's trichrome. Further, it is utilized in tissue stain.

Uses

Fast Green FCF is a colorant. It has good ph stability, showing after 1 week a slight fade at ph 3, a very slight fade at ph 5 to 7, and slight fade and appreciably bluer color at ph 8. It has excellent solubility in water with a solubility of 20 g in 100 ml at 25°c. It has fair to good stability to light, poor stability to oxidation, and shows no appreciable change in 10% sugar systems. It has a bluish-green hue, with excellent tinctorial strength. It has good compatibility with food components and is occasionally used in cereals, soft drinks, beverages, and desserts.

Uses

Biological stain. Color additive in food, drugs and cosmetics.

Definition

ChEBI: An organic sodium salt having 2-{(4-{ethyl[(3-sulfonatophenyl)methyl]amino}phenyl)[4-{ethyl[(3-sulfonatophenyl)methyl]iminio}cyclohexa-2,5-dien-1-ylidene]methyl}-5-hydroxybenzene-1-sulfonate as the counterion. Used as a substitute for Light green SF yellow sh in Masson's trichrome as it is less likely to fade, and is more brilliant in colour. Also used as a food colouring agent.

General Description

Fast Green FCF is one of the triarylmethane dyes, that is biocompatible. This triphenylmethane color additive is mainly used in coloring food, drugs and cosmetics.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Fast Green FCF can be considered as a safe stain to detect tumor. In recent years, this has gained importance as an important drug to treat amyloid-deposit diseases.

Properties and Applications

blue light green. Soluble in water for blue light green, soluble in ethanol for blue light green. The strong sulfuric acid for dark orange, diluted dark for; In strong hydrochloric acid or nitric acid are all the orange solution; In 10% of sodium hydroxide solution for light blue.

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