2-[2-[2-[2-[(tert-Butyldimethylsilanyl)oxy]ethoxy]ethoxy]ethoxy]ethanol Chemical Properties

Density 

0.959 g/mL at 25 °C

refractive index 

n20/D1.447

Flash point:

>110℃

storage temp. 

Storage temp. 2-8°C

pka

14.36±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

Boiling point:

330-338°C/760 mmHg

InChI

InChI=1S/C14H32O5Si/c1-14(2,3)20(4,5)19-13-12-18-11-10-17-9-8-16-7-6-15/h15H,6-13H2,1-5H3

InChIKey

KZFZMISGZPOLJM-UHFFFAOYSA-N

SMILES

C(O)COCCOCCOCCO[Si](C)(C)C(C)(C)C

Safety Information

Hazard Codes 

T

Risk Statements 

25-38

Safety Statements 

45

RIDADR 

UN 2810 6.1 / PGIII

WGK Germany 

3

2-[2-[2-[2-[(tert-Butyldimethylsilanyl)oxy]ethoxy]ethoxy]ethoxy]ethanol Usage And Synthesis

Description

TBDMS-PEG5 is a PEG linker containing a TBDMS alcohol protecting group and a terminal hydroxyl group. TBDMS can be removed in the presence of acetyl chloride. The terminal hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of compounds in aqueous environments.

Uses

TBDMS-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

2-[2-[2-[2-[(tert-Butyldimethylsilanyl)oxy]ethoxy]ethoxy]ethoxy]ethanol(134179-40-1)Related Product Information

• TBDMS-PEG4-Acid
• Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 13,13,14,14-tetramethyl-3,6,9,12-tetraoxa-13-silapentadec-1-yl ester