(S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID Chemical Properties

Melting point:

68-70 °C (lit.)

Boiling point:

124-125 °C/13 mmHg (lit.)

Density 

1.136

refractive index 

1.4641 (estimate)

Flash point:

112℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml

pka

3.87±0.16(Predicted)

form 

Powder

color 

White

optical activity

[α]20/D +19°, c = 1 in chloroform

BRN 

1721140

CAS DataBase Reference

17407-55-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10

Hazard Note 

Irritant

HS Code 

29181990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

(S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID Usage And Synthesis

Chemical Properties

white fine crystalline powder

Uses

A useful chiral building block for peptide synthesis. Used in the preparation of the cytotoxic didemnin cyclopeptides and of the antineoplastic agent dolastatin 15.

Definition

ChEBI: (S)-2-hydroxy-3-methylbutyric acid is the S-enantiomer of 2-hydroxy-3-methylbutyric acid. It is used as a chiral building block for peptide synthesis. It has a role as a chiral reagent and a human metabolite. It is a conjugate acid of a (S)-2-hydroxy-3-methylbutyrate. It is an enantiomer of a (R)-2-hydroxy-3-methylbutyric acid.

(S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID(17407-55-5)Related Product Information

• Azadirachtin
• MONOCROTALINE
• D-(-)-PANTOLACTONE
• (S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID
• PICROTOXIN
• AZADIRACHTIN H(SH)
• RETRORSINE
• PICROTOXININ
• (S)-(+)-2-Amino-3-hydroxy-3-methylbutanoic acid
• (R)-Methyl 2-hydroxy-3-methylbutanoate
• 4-Hydroxy-2-methylbutyric acid lactone,4-Hydroxy-2-methylbutyric acid lactone
• 3-Hydroxy-2-methylbutyric acid,3-Hydroxy-2-methylbutyric acid
• D-beta-Hydroxyvaline
• (2R)-2-Hydroxy-3-methylbutyric acid
• 2-HYDROXY-2-METHYLBUTYRIC ACID,2-HYDROXY-2-METHYLBUTYRIC ACID
• beta-Hydroxyisovaleric Acid
• 2-(S)-Hydroxy-3-methylbutyric acid methyl ester,2-(S)-Hydroxy-3-methylbutyric acid methyl ester
• 4,4,4-TRIFLUORO-3-HYDROXY-3-METHYLBUTYRIC ACID,4,4,4-TRIFLUORO-3-HYDROXY-3-METHYLBUTYRIC ACID