(3-BROMOTHIOPHEN-2-YL)METHANOL Chemical Properties

Boiling point:

147-148 °C(Press: 20 Torr)

Density 

1.772±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

13.16±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2934999090

(3-BROMOTHIOPHEN-2-YL)METHANOL Usage And Synthesis

Synthesis

General procedure for the synthesis of (3-bromothiophen-2-yl)methanol from 3-bromothiophene-2-carboxaldehyde: 3-bromothiophene-2-carboxaldehyde (500 mg, 2.62 mmol) was dissolved in methanol (10 mL) at 0 °C, sodium borohydride (169 mg, 4.47 mmol) was added in batches, and the reaction mixture was stirred and reacted at 0 °C for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporation. The residue was separated by extraction with ethyl acetate (20 mL) and 10% ammonium chloride solution (10 mL). The organic layer was washed with water (10 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give (3-bromothiophen-2-yl)methanol (505 mg, 2.62 mmol, 100% yield) as a yellow oil.

References

[1] Patent: WO2011/156640, 2011, A2. Location in patent: Page/Page column 134
[2] Patent: WO2013/86451, 2013, A2. Location in patent: Paragraph 00473
[3] Journal of the American Chemical Society, 2014, vol. 136, # 19, p. 7132 - 7139
[4] Chemical Communications, 2015, vol. 51, # 18, p. 3842 - 3845

(3-BROMOTHIOPHEN-2-YL)METHANOL(70260-17-2)Related Product Information

• 3-Bromothiophene-2-carboxylic acid
• METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE
• 3-BROMOTHIOPHENE-2-CARBOXALDEHYDE DIETHYL ACETAL
• ETHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE
• 3-BROMOTHIOPHEN-2,4-DICARBOXYLIC ACID
• (3-BROMOTHIOPHEN-2-YL)METHANOL
• 3-BROMOBENZOTHIOPHENE-2-CARBOXYLIC ACID&
• methyl 3-bromo-5-(nitro)thiophene-2-carboxylate
• SPECS AI-942/25034511
• BUTTPARK 85\04-58
• 3-BROMO-2-THIENYL-(3-FURYL)METHANOL
• RARECHEM AL BP 0362
• 3-BROMO-5-NITRO-2-THIOPHENECARBOXYLIC ACID
• 3-BROMO-2-THIENYL-(1-METHYL-2-PYRROLYL)METHANOL
• SPECS AI-942/25034128
• SPECS AI-942/25034100
• 3-BROMO-2-(1-METHOXYETHYL)-5-NITROTHIOPHENE
• BUTTPARK 85\04-56