TETRAETHYL PYROPHOSPHITE Chemical Properties

Boiling point:

79-81 °C/1 mmHg (lit.)

Density 

1.057 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.434(lit.)

Flash point:

>230 °F

solubility 

Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)

form 

Oil

color 

Colourless

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

TETRAETHYL PYROPHOSPHITE Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Tetraethyl Pyrophosphite is used as a reagent in the preparation of peptides and in the phosphonylation of carbonyl compounds.

Uses

The product can be used as a reagent for peptide synthesis.

Application

Tetraethyl pyrophosphite can be used in peptide synthesis; phosphonylation of ketones, aldehydes, and perfluoroalkyl iodides.

Preparation

The most convenient method involves the reaction of diethyl phosphite with diethyl  phosphorochloridite. Diethyl phosphorochloridite (223 g) is added rapidly to a solution of diethyl phosphite (138 g) and  triethylamine (101 g) in benzene (200 ml). The mixture is filtered and the benzene removed by distillation at reduced  pressure. The product is isolated by further distillation at reduced pressure (79-81 °C/0.15 mmHg) in 41% yield.

TETRAETHYL PYROPHOSPHITE(21646-99-1)Related Product Information

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