HEMATOPORPHYRIN DIHYDROCHLORIDE
HEMATOPORPHYRIN DIHYDROCHLORIDE Basic information
- Product Name:
- HEMATOPORPHYRIN DIHYDROCHLORIDE
- Synonyms:
-
- 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr
- 21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr
- 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid
- acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor
- ematoporfirina
- HEMATOPORPHYRIN IX DIHYDROCHLORIDE
- HEMATOPORPHYRIN DIHYDROCHLORIDE
- HAEMATOPORPHYRIN DIHYDROCHLORIDE
- CAS:
- 17696-69-4
- MF:
- C34H39ClN4O6
- MW:
- 635.16
- EINECS:
- 241-699-4
- Product Categories:
-
- Natural Porphyrins and Derivitives
- Porphyrins
- Biochemistry
- Miscellaneous Biochemicals
- porphine (porphyrin) ligand
- Mol File:
- 17696-69-4.mol
HEMATOPORPHYRIN DIHYDROCHLORIDE Chemical Properties
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Very Dark Red
- Water Solubility
- Insoluble in water. Soluble in pyridine (5%).
- Merck
- 14,4636
- BRN
- 78957
- Stability:
- Hygroscopic
- EPA Substance Registry System
- 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4)
Safety Information
- Risk Statements
- 33
- RTECS
- TS5505000
- TSCA
- Yes
- Toxicity
- mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978.
MSDS
- Language:English Provider:ALFA
HEMATOPORPHYRIN DIHYDROCHLORIDE Usage And Synthesis
Description
Hematoporphyrin is a photosensitizer. Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria. It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM. Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation.
Uses
Endogenous porphyrin formed by the acid hydrolysis of hemoglobin. It is employed as an active pharmaceutical intermediate.
References
[1] KESSEL D. Hematoporphyrin and HPD: photophysics, photochemistry and phototherapy.[J]. Photochemistry and Photobiology, 1984, 39 6: 851-859. DOI: 10.1111/j.1751-1097.1984.tb08871.x
[2] C SALET G M. Photodynamic effects of haematoporphyrin on respiration and calcium uptake in isolated mitochondria.[J]. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1981, 39 2: 227-230. DOI: 10.1080/09553008114550261
[3] M. EGYEKI . DNA damaging capability of hematoporphyrin towards DNAs of various accessibilities[J]. Journal of photochemistry and photobiology. B, Biology, 2006, 84 2: Pages 119-127. DOI: 10.1016/j.jphotobiol.2006.02.005
[4] L TOMIO. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats.[J]. Acta radiologica. Oncology, 1983, 22 1: 49-53. DOI: 10.3109/02841868309134338
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HEMATOPORPHYRIN DIHYDROCHLORIDE(17696-69-4)Related Product Information
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- Allylacetic acid
- PORPHINE
- HEMATOPORPHYRIN DIHYDROCHLORIDE
- 7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid
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- HEMATOPORPHYRIN HYDROCHLORIDE
- DEUTEROPORPHYRIN IX DIHYDROCHLORIDE