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HEMATOPORPHYRIN DIHYDROCHLORIDE

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HEMATOPORPHYRIN DIHYDROCHLORIDE Basic information

Product Name:
HEMATOPORPHYRIN DIHYDROCHLORIDE
Synonyms:
  • 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr
  • 21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr
  • 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid
  • acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor
  • ematoporfirina
  • HEMATOPORPHYRIN IX DIHYDROCHLORIDE
  • HEMATOPORPHYRIN DIHYDROCHLORIDE
  • HAEMATOPORPHYRIN DIHYDROCHLORIDE
CAS:
17696-69-4
MF:
C34H39ClN4O6
MW:
635.16
EINECS:
241-699-4
Product Categories:
  • Natural Porphyrins and Derivitives
  • Porphyrins
  • Miscellaneous Biochemicals
  • Biochemistry
  • porphine (porphyrin) ligand
Mol File:
17696-69-4.mol
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HEMATOPORPHYRIN DIHYDROCHLORIDE Chemical Properties

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Very Dark Red
Water Solubility 
Insoluble in water. Soluble in pyridine (5%).
Merck 
14,4636
BRN 
78957
Stability:
Hygroscopic
EPA Substance Registry System
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4)
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Safety Information

Risk Statements 
33
RTECS 
TS5505000
TSCA 
Yes
Toxicity
mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978.

MSDS

  • Language:English Provider:ALFA
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HEMATOPORPHYRIN DIHYDROCHLORIDE Usage And Synthesis

Description

Hematoporphyrin is a photosensitizer. Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria. It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM. Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation.

Uses

Endogenous porphyrin formed by the acid hydrolysis of hemoglobin. It is employed as an active pharmaceutical intermediate.

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