BETA-NERVE GROWTH FACTOR, HUMAN Chemical Properties

storage temp. 

-20°C

form 

lyophilized powder

biological source

rat

Water Solubility 

water: soluble 0.1g/L at20°C

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

BETA-NERVE GROWTH FACTOR, HUMAN Usage And Synthesis

Uses

NGF-β human has been used:

• in protein pin arrays
• to induce U87-MG (glioblastoma cell line) cell proliferation
• in drug release kinetics

General Description

NGFβ (nerve growth factor β) is a protein involved in signal transduction, and expressed by multiple tissues such as placenta, urothelium and bladder smooth muscle cells. It is a neurotrophin and belongs to the NGF family.

Biochem/physiol Actions

NGFβ (nerve growth factor β) is essential for the differentiation and survival of neurons. It also plays a key role in the development and maintenance of nervous system. It is also involved in angiogenesis, and facilitates tumorigenesis such as, oral, breast and prostate cancers. It has potential as marker for the diagnosis of interstitial cystitis/painful bladder syndrome (IC/PBS) and overactive bladder (OAB), and might also aid in determining the therapy for the same. It might be involved in changes in placental function, as NGF signaling is influenced by antenatal depression and selective serotonin reuptake inhibitor (SSRI) treatment.

Description

Pro-NGF Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 224 amino acids and having a molecular mass of 25 kDa.
ProNGF Human Recombinant is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

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