CHOLESTA-3,5-DIENE
CHOLESTA-3,5-DIENE Basic information
- Product Name:
- CHOLESTA-3,5-DIENE
- Synonyms:
-
- Cholestadiene
- delta-(sup3,5)-cholestadien
- delta(Sup3,5)-Cholestadiene
- delta-3,5-Cholestadien
- delta-3,5-Cholestadiene
- CHOLESTERILENE
- CHOLESTA-3,5-DIENE
- CHOLEST-3,5-DIENE
- CAS:
- 747-90-0
- MF:
- C27H44
- MW:
- 368.64
- EINECS:
- 212-021-4
- Product Categories:
-
- Cholesterol and Derivatives
- Lipids
- Sterols
- Mol File:
- 747-90-0.mol
CHOLESTA-3,5-DIENE Chemical Properties
- Melting point:
- 78-80 °C (lit.)
- Boiling point:
- 433.93°C (rough estimate)
- Density
- 0.9250
- refractive index
- 1.4922 (estimate)
- storage temp.
- -20°C
- form
- Solid
- color
- White to off-white
- biological source
- natural (organic)
MSDS
- Language:English Provider:SigmaAldrich
CHOLESTA-3,5-DIENE Usage And Synthesis
Uses
Cholesta-3,5-diene was used as standard in HPLC in quality analysis of different types of olive oils and edible fats.
Definition
ChEBI: Cholesta-3,5-diene is a cholestanoid.
Biochem/physiol Actions
Cholesta-3,5-diene is an oxysterol, a cholesterol derivative by auto-oxidation. Oxysterols are non-genomic regulators of cholesterol homeostasis. The biological effects include protein prenylation, apoptosis, modulation of sphingolipid metabolism and platelet aggregation. Oxysterols bind to liver X receptors, modulate cholesterol efflux and decrease the uptake of cholesterol by the cells.
in vivo
Neutrophil Recruitment: Cholesta-3,5-diene (30 μg/ml; topical application; single dose) promotes neutrophil recruitment to tailfin wounds in transgenic zebrafish larvae (Tg(mpx:GFP)) by 6 h post-treatment1.
Tissue Regeneration: Cholesta-3,5-diene (30 μg/ml; topical application; single dose) does not enhance tissue regeneration in zebrafish tailfin wounds, unlike the lipid fraction Ft containing Cholesta-3,5-diene1.
| Animal Model: | Transgenic zebrafish larvae (Tg(mpx:GFP), 4 days post-fertilization, male/female mixed, 200-300 mg)[1] |
| Dosage: | 30 μg/mL Cholesta-3,5-diene (dissolved in ethanol, diluted in E2 medium) |
| Administration: | Topical application to transected tailfin immediately after wounding, single dose |
| Result: | Significantly increased neutrophil accumulation at the wound site by 6 h post-treatment (2-fold vs. vehicle control. No effect was observed in uninjured tailfins[1]. |
| Animal Model: | Transgenic zebrafish larvae (Tg(mpx:GFP), 4 days post-fertilization, male/female mixed, 200-300 mg)1 |
| Dosage: | 30 μg/mL Cholesta-3,5-diene (dissolved in ethanol, diluted in E2 medium) |
| Administration: | Topical application to transected tailfin immediately after wounding, single dose |
| Result: | Did not promote significant tissue regeneration at 2 or 6 days post-treatment, unlike the lipid fraction Ft (which showed dose-dependent regeneration). Resulted maximum regeneration with Ft of 50 μg/mL. |
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CHOLESTA-3,5-DIENE(747-90-0)Related Product Information
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- Acetic acid cholesta-5,7-diene-3β-yl ester
- (22E,24R)-24-Methyl-5α-cholesta-7,22-diene-3β,5,6β-triol
- 3,5-CHOLESTADIEN-3-OL 3-ACETATE
- cholesta-5,7-diene-1alpha,3beta-diyl diacetate ,Diacetic acid cholesta-5,7-diene-1α,3β-diyl ester,Cholesta-5,7-diene-1α,3β-diol diacetate
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- Cholesta-2,4-diene
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- 3,3'-BIS(3,5-CHOLESTADIENE)
- CHOLESTA-3,5-DIENE
- cholesta-3,5-dien-7-one
- Cholesta-4,6-diene
- (24R)-Cholesta-5,7-diene-3β,24,25-triol
- Cholesta-4,6-diene-3β-ol acetate
- (22E,24S)-24-Ethyl-5α-cholesta-7,22-diene-3β,5,6β-triol 3,6-diacetate
- 5α-Cholesta-2,6-diene
- 5α-Cholesta-7,14-diene-3β,5,6α,20,25-pentol 3-(dihydrogen phosphate)
- 3β-(Trimethylsilyloxy)cholesta-5,24-diene