Terazosin hydrochloride Chemical Properties

Melting point:

261-263°C

storage temp. 

Inert atmosphere,2-8°C

solubility 

H₂O: 25 mg/mL

form 

powder

color 

white to off-white

Water Solubility 

Soluble in water at 20mg/ml. Also soluble in methanol or ethanol.

Stability:

Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.

CAS DataBase Reference

63074-08-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

TK8044925

MSDS

• Language:English Provider:SigmaAldrich

Terazosin hydrochloride Usage And Synthesis

Description

Terazosin hydrochloride is a highly water-soluble antihypertensive agent with a structure and profile closely related to that of prazosin.

Originator

Abbott (USA)

Uses

An α-1-adrenergicblocker related to prazosin.

Uses

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies⁵. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods⁶.

Uses

Hytrin (Abbott).

brand name

Terazosin is INN and BAN;HEITRIN.

General Description

Terazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride (Hytrin), is a structuralcongener of prazosin hydrochloride. It possessessimilar selective properties of specifically inhibiting 1-adrenergic receptors. The drug is slightly less potent thanprazosin hydrochloride. Terazosin hydrochloride has a halflifeof approximately 12 hours, which is much longer thanthat of prazosin. This lends itself to a once-daily dose tocontrol hypertension in many patients.

Biological Activity

α 1 - and α 2B -adrenoceptor antagonist (K i values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α 1A , α 1B , α 1D , α 2B , α 2A and α 2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo .

Biochem/physiol Actions

α1-adrenoceptor antagonist.

storage

Store at RT

References

References/Citations 1) Hancock et al. (1995), Actions of terazosin and its enantiomers at subtypes of alpha-1 and alpha-2 adrenoceptors in vitro; Recept. Signal Transduct. Res., 15 863 2) Kyncl et al. (1986), Pharmacology of terazosin; Am. J. Med., 80 12 3) Shionoiri et al. (1994), Long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensives: a multicenter prospective study; Am. J. Med. Sci., 307 Suppl 1 S91 4) Pan et al. (2003), Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells; J. Urol., 169 724 5) Chen et al. (2015), Terazosin activates Pgk1 and HSP90 to promote stress resistance; Nat. Chem. Biol., 11 19

Terazosin hydrochloride(63074-08-8)Related Product Information

• TERAZOSIN HYDROCHLORIDE DIHYDRATE
• Cetirizine dihydrochloride
• Telmisartan
• 4-Amino-6,7-dimethoxyquinazoline
• Terazosin
• Quinazoline
• Terazosin hydrochloride
• TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. O (EP): 1,4-BIS[(TETRAHYDROFURAN-2-YL)CARBONYL]PIPERAZINE
• TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. N (EP): 1-[[(2RS)-TETRAHYDROFURAN-2-YL]CARBONYL]PIPERAZINE
• TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. K (EP) AS HYDROCHLORIDE:PRAZOSIN HYDROCHLORIDE
• TERAZOSIN HYDROCHLORIDE MONOHYDRATE
• TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. M (EP): 1,4-BIS(FURAN-2-YLCARBONYL)PIPERAZINE
• (R)-(+)-TERAZOSIN HYDROCHLORIDE DIHYDRATE
• Terazosin hydrochloride, anhydrous
• TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. L (EP): 1-(FURAN-2-YLCARBONYL)-PIPERAZINE
• TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. C (EP): 6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE
• TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. A (EP): 2-CHLORO-6,7-DIMETHOXYQUINAZOLIN-4-AMINE