Sulfamerazine sodium Chemical Properties

RTECS 

WP0760000

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Powder

Water Solubility 

Soluble in DMSO or water

CAS DataBase Reference

127-58-2(CAS DataBase Reference)

EPA Substance Registry System

Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-, monosodium salt (127-58-2)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/22-36/38-36/37/38

Safety Statements 

7-24-45-36-26

WGK Germany 

3

TSCA 

Yes

MSDS

• Language:English Provider:SigmaAldrich

Sulfamerazine sodium Usage And Synthesis

Description

Sulfamerazine is a sulfonamide antibiotic. It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM. In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice. It also prevents death of Toxoplasma-infected mice. Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid for binding to dihydropteroate synthase. Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.

Uses

Involved in characterization of chirosan membranes for the transport of drugs1,2,3

brand name

Bio hubber simple;Cremo-merazine;Debnal m;Mebacid;Neotrizine;Peccocode;Septosil;Spanbolet ii;Tersulpha;Trisulfaminic;Trisulpha.

World Health Organization (WHO)

Sulfamerazine sodium, a sulfonamide anti-infective agent, was introduced several decades ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfamerazine is still used in some countries usually in combination with other sulfonamides.

Safety Profile

Moderately toxic by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.

Sulfamerazine sodium(127-58-2)Related Product Information

• Sulfamethazine
• Sulfadiazine
• Sodium sulfadiazine
• METSULFURON METHYL
• Sodium citrate
• Sodium bicarbonate
• Sulfadimethoxine
• Methyl salicylate
• Sodium hydroxide
• Sodium chloride
• Sodium sulfate
• Silver sulfadiazine
• Sulfamerazine
• Sodium acetate
• Methyl acetate
• Sodium chlorite
• Tribenuron methyl
• Diclofenac sodium