SIR2L Chemical Properties

storage temp. 

-70°C

form 

buffered aqueous glycerol solution

biological source

human

Specific Activity

6120-10580RLU/min·ng

Safety Information

Hazard Codes 

T

Risk Statements 

61

Safety Statements 

53-45

SIR2L Usage And Synthesis

Uses

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biological Activity

Silent information regulator 2 (Sir2) acts as a nicotine adenine dinucleotide (NAD) dependent deacetylase and is implicated in various biological processes such as regulation of transcriptional repression, recombination, the cell-division cycle, microtubule organization, and cellular responses to DNA-damaging agents. In addition, sirtuins also regulate the process involved in aging. Sir2 plays a vital role in mammalian metabolic homeostasis and is considered to be a potent therapeutic target for the treatment of type 2 diabetes. Sir2 has a crucial role in reduction of microglial activation and brain inflammation. Therefore, loss of Sir2 activity increases the risk of susceptibility to neurodegenerative diseases.

SIR2L()Related Product Information

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