DBCO-PEG4-Acid Chemical Properties

Boiling point:

839.7±65.0 °C(Predicted)

Density 

1.27±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO, DCM, DMF

form 

Solid or Viscous Liquid

pka

4.28±0.10(Predicted)

color 

Yellow to Orange

InChIKey

LKSAMQQFMTVPKD-UHFFFAOYSA-N

SMILES

C(O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O

DBCO-PEG4-Acid Usage And Synthesis

Description

DBCO-PEG4-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG spacer adds hydrophilicity to the product to decrease aggregation.

reaction suitability

reaction type: click chemistry
reagent type: linker

IC 50

PEGs

DBCO-PEG4-Acid(1537170-85-6)Related Product Information

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• DBCO-PEG4-triethoxysilane
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• DBCO-PEG3-OH