(S)-2-Benzylsuccinic acid Chemical Properties

Melting point:

164.0 to 168.0 °C

Boiling point:

331.4±22.0 °C(Predicted)

Density 

1.290±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

3.97±0.10(Predicted)

color 

White to Almost white

InChI

InChI=1S/C11H12O4/c12-10(13)7-9(11(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,12,13)(H,14,15)/t9-/m0/s1

InChIKey

GTOFKXZQQDSVFH-VIFPVBQESA-N

SMILES

C(O)(=O)[C@@H](CC1=CC=CC=C1)CC(O)=O

CAS DataBase Reference

3972-36-9(CAS DataBase Reference)

Safety Information

HS Code 

29173990

(S)-2-Benzylsuccinic acid Usage And Synthesis

Description

(S)-2-Benzylsuccinic acid is a widely used compound, which was employed as a key intermediate for hypoglycemic KAD-1229 by means of asymmetric alkylation of N-acylsulta. It can be synthesized by various procedures. The preparation of (S)-2-benzylsuccinic acid from L-phenylalanine is considered to be one of the most clean, efficient and convenient processes. The compound is a common chiral synthesis intermediate.

Uses

(S)-2-Benzylsuccinic acid is a common asymmetric synthesis intermediate in which the carboxyl group in the structure can be converted to common active functional groups, such as hydroxyl groups under the reduction of boranes. In addition, the two carboxyl groups in the structure can be heated and dehydrated and condensed in the presence of acetic anhydride or acetyl chloride to obtain the corresponding anhydride structure.

(S)-2-Benzylsuccinic acid(3972-36-9)Related Product Information

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