2,4-DIMETHYLBENZYL BROMIDE Chemical Properties

Melting point:

15℃

Boiling point:

235℃

Density 

1.314

refractive index 

1.568-1.57

Flash point:

102℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

Liquid

color 

Clear colorless to light yellow

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

RIDADR 

3265

HS Code 

29036990

MSDS

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2,4-DIMETHYLBENZYL BROMIDE Usage And Synthesis

Chemical Properties

clear colorless to light yellow liquid

Synthesis

General procedure for the synthesis of 2,4-dimethylbenzyl bromide from (2,4-dimethylphenyl)methanol: 1. to a solution of diisopropyl ether (100 mL) of (2,4-dimethylphenyl)methanol (10.77 g) was slowly added phosphorus tribromide (4.90 mL) at 0 °C. 2. The reaction mixture was stirred at room temperature for 1 hour. 3. Upon completion of the reaction, water was added to the mixture and extracted with ethyl acetate. 4. The organic phases were combined and washed twice with water, saturated aqueous sodium bicarbonate and saturated brine in that order. 5. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 2,4-dimethylbenzyl bromide as a colorless oil (15.5 g, quantitative yield). 6. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 2.30 (3H, s), 2.37 (3H, s), 4.50 (2H, s), 6.96-6.99 (2H, m), 7.17-7.19 (1H, m).

References

[1] Patent: EP1787991, 2007, A1. Location in patent: Page/Page column 45
[2] Canadian Journal of Chemistry, 1986, vol. 64, p. 1060 - 1071
[3] Journal of Medicinal Chemistry, 1989, vol. 32, # 8, p. 1757 - 1763
[4] Polish Journal of Chemistry, 2007, vol. 81, # 5-6, p. 947 - 969
[5] Patent: US2007/129365, 2007, A1. Location in patent: Page/Page column 12

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