1-Methyl-3-pyrrolidinol Chemical Properties

Boiling point:

50-52 °C1 mm Hg(lit.)

Density 

0.921 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.464(lit.)

Flash point:

159 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

pka

14.95±0.20(Predicted)

color 

Colourless

InChI

InChI=1S/C5H11NO/c1-6-3-2-5(7)4-6/h5,7H,2-4H2,1H3

InChIKey

FLVFPAIGVBQGET-UHFFFAOYSA-N

SMILES

N1(C)CCC(O)C1

CAS DataBase Reference

13220-33-2(CAS DataBase Reference)

NIST Chemistry Reference

1-Methyl-3-pyrrolidinol(13220-33-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

HS Code 

29339900

MSDS

• Language:English Provider:1-Methylpyrrolidin-3-ol
• Language:English Provider:SigmaAldrich

1-Methyl-3-pyrrolidinol Usage And Synthesis

Chemical Properties

Clear colorless to pale yellow liquid

Uses

1-Methyl-3-pyrrolidinol (cas# 13220-33-2) is a compound useful in organic synthesis.

Synthesis

A 500 mL four-necked flask was charged with a 40 wt% aqueous solution of monomethylamine and cooled to 10 ° C in an ice-water bath. Then, while stirring, 1,4-dichloro-2-butanol was added dropwise, and the temperature was controlled at 15 ° C. Then pour the system into an Autoclave, sealed, evacuated to a pressure of 1.0 ± 0.1MPa, while heated to 120 ℃, the reaction was stirred for about 10h. After the reaction was over and cooled to room temperature, the material was discharged, batch-wise added sodium hydroxide was released, and a large amount of methylamine gas, controlling the temperature below 50 ℃, precipitated a lot of white solid, stirred for 1h; filtration, the filtrate layered, the upper organic phase Ethanol And anhydrous magnesium sulfate, stirring 2 ~ 3h; and then filtered, the filtrate was concentrated in vacuo to give a yellow transparent oily liquid, and then vacuum distillation to give colorless and t1-Methyl-3-pyrrolidinol, Yield 64.8%, purity 99.3%.

1-Methyl-3-pyrrolidinol(13220-33-2)Related Product Information

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