Basic information Safety Supplier Related

DBCO-maleimide

Basic information Safety Supplier Related

DBCO-maleimide Basic information

Product Name:
DBCO-maleimide
Synonyms:
  • DBCO-maleimide
  • Dibenzocyclooctyne-maleimide
  • Dibenzocyclooctyne-maleimide (This product is unavailable in the U.S.)
  • 1H-Pyrrole-1-propanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-2,5-dihydro-2,5-dioxo-
  • DBCO-Maleimide,Dibenzocyclooctyne-maleimide
  • DBCO-maleimide (This product is unavailable in the U.S.)
  • DBCO-maleimide (This product is unavailable in the U.S.) (2mg*5)
  • N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide
CAS:
1395786-30-7
MF:
C25H21N3O4
MW:
427.45
Product Categories:
  • ADC LINKER
Mol File:
1395786-30-7.mol
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DBCO-maleimide Chemical Properties

Melting point:
162 °C
Boiling point:
790.5±60.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO, DCM, DMF
form 
Solid
pka
15.03±0.46(Predicted)
color 
Off-white to Gray
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Safety Information

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
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DBCO-maleimide Usage And Synthesis

Description

DBCO-Maleimide is a sulfhydryl reactive reagent containing a maleimide group and a DBCO moiety. Maleimide group specifically and efficiently reacts with thiols to form thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety into cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification

Uses

Dbco-Maleimide is used in preparation of radioactive metal indicator-chelating peptide derivative-conjugated antibodies for medical imaging.

DBCO-maleimideSupplier

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