DBCO-SE Chemical Properties

Melting point:

149-157 (decomposition)

storage temp. 

-20°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Moisture Sensitive

DBCO-SE Usage And Synthesis

Uses

Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

• Protein-peptide conjugates
• Antibody-enzyme or antibody-drug conjugates
• Protein or peptide-oligonucleotide conjugates
• Surface modification

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

DBCO-SE()Related Product Information

• DBCO-PEG5-NHS ester
• Diazo Biotin-PEG3-DBCO
• PC DBCO-PEG3-Biotin
• Desthiobiotin-PEG4-DBCO
• 2-(4-Ethyl-1-piperazinyl)-4-[4-(4-ethyl-1-piperazinyl)phenyl]-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
• DBCO-PEG4-SE