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Cefodizime sodium

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Cefodizime sodium Basic information

Product Name:
Cefodizime sodium
Synonyms:
  • )(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio
  • 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)th5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicaci
  • 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid
  • disodiumsalt,(6r-(6-alpha,7-beta(z)))-)methyl)-8-oxo
  • thr-221
  • 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid disodium salt
  • Cefodizimedisodiumsalt
  • kenicef
CAS:
86329-79-5
MF:
C20H21N6NaO7S4
MW:
608.65
Mol File:
86329-79-5.mol
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Cefodizime sodium Chemical Properties

Melting point:
196 - 207°C
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Sparingly)
form 
powder
color 
White to Off-White
Stability:
Hygroscopic
CAS DataBase Reference
86329-79-5(CAS DataBase Reference)
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Safety Information

Toxicity
LD50 in mice, rabbits (mg/kg): 4000-8000 i.v. both species; in rats (mg/kg): 4000-8000 i.v., 15000-17500 s.c., 8000-11000 i.p. (Bryskier)
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Cefodizime sodium Usage And Synthesis

Description

Cefodizirne sodium is a parenteral, long-acting, broad-spectrum cephalosporin useful in the treatment of bacterial infections. It is efficacious against pathogens resistant to penicillins and older cephalosporins. An indication under study is its reported immunostimulatory activity.

Originator

Hoechst AG (Germany)

Uses

Cefodizime Sodium (cas# 86329-79-5) is a compound useful in organic synthesis.

Definition

ChEBI: Cefodizime sodium is a cephalosporin.

brand name

Neucef; Kenicef

Hazard

Low toxicity by ingestion.

Biochem/physiol Actions

Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime was demonstrated to be effective against upper and lower respiratory tract infections, urinary tract infections, and gonorrhea. Cefodizime regulates the cytokines expression of neutrophils through toll-like receptor 4 (TLR-4) stimulated by Klebsiella pneumonie.

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