2-Fluoro-5-trifluoromethylpyridine Chemical Properties

Boiling point:

118-122℃

Density 

1.368 g/mL at 25 °C

Flash point:

35°(95°F)

refractive index 

1.4020

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

clear liquid

pka

-2.86±0.10(Predicted)

color 

Colorless to Almost colorless

CAS DataBase Reference

69045-82-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

20/21/22-36/37/38-52/53-43-10

Safety Statements 

26-36/37/39-45-61-37-24-36-27

RIDADR 

1993

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

Ⅲ

HS Code 

29333990

2-Fluoro-5-trifluoromethylpyridine Usage And Synthesis

Chemical Properties

Colorless liquid

Synthesis

In a 1-liter three-necked flask, 46.20g (0.80 mol) of KF was added, followed by 500 mL of N, N-dimethylacetamide, which was warmed to 125 °C and stirred for 30 minutes. The setup was then connected to a distillation unit for micro-vacuum distillation, during which fractions were collected, and the water content was monitored using three separate bottles. Distillation was halted when the water content reached less than 500 ppm. Subsequently, 7g (0.03 mol) of benzyl triethyl ammonium chloride and 100g (0.55 mol) of 2-chloro-5-trifluoromethylpyridine were added to the flask. A condenser was connected, and the mixture was warmed to 135 °C and stirred for 10 hours. Gas chromatography was used to monitor the reaction; the reaction was stopped when the content of 2-chloro-5-trifluoromethylpyridine in the reaction solution was less than 1%. The reaction solution was directly distilled under reduced pressure to collect the fraction at 40-45 °C / 11 mmHg, yielding 87.80g of 2-fluoro-5-trifluoromethylpyridine with a purity of 98.95% (GC) and a yield of 95.56%.

2-Fluoro-5-trifluoromethylpyridine (69045-82-5)Related Product Information

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• 5-Chloro-2-fluoropyridine
• 2-Fluoropyridine-6-carboxylic acid
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• 2-CHLORO-6-FLUOROPYRIDINE
• 4-Bromo-2-fluoropyridine
• 3-Bromo-2-fluoro-5-methylpyridine
• 2-Fluoro-3-methylpyridine
• 3-Amino-2-fluoropyridine
• 3-Chloro-2-fluoro-pyridine
• 2-Fluoro-5-methylpyridine
• 2-Fluoro-4-methylpyridine
• 3-BROMO-5-CHLORO-2-FLUOROPYRIDINE
• 5-BROMO-2-FLUORO-6-PICOLINE
• 3-Chloro-2-iodopyridine