FORMOTEROL-D3 Usage And Synthesis

Uses

Formoterol-d3 is deuterium labeled Arformoterol. Arformoterol ((R,R)-Formoterol), the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD)[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Handley DA, et, al. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002;15(2):135-45. DOI:10.1006/pupt.2001.0327
[3] Cazzola M, et, al. Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr;4(2):155-62. DOI:10.1586/ers.10.16
[4] Song W, et, al. Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am J Respir Cell Mol Biol. 2011 Jul;45(1):88-94. DOI:10.1165/rcmb.2010-0226OC

FORMOTEROL-D3(1198353-13-7)Related Product Information

• Formoterol fumarate
• Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [S-(R*,S*)]-
• Formoterol O-β-D-Glucuronide
• Formoterol EP Impurity F
• (S,S)-Formoterol
• ForMoterol-IMpurity-B
• Formoterol EP Impurity C
• 1-(4-Methoxyphenyl)-2-benzylaminopropane
• Formoterol Impurity 13
• Formoterol EP Impurity D
• (R)-2-(4-Methoxyphenyl)-1-methylethanamine
• Formoterol Fumarate Dihydrate EP Impurity I
• 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
• Formoterol EP Impurity E
• Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [R-(R*,S*)]-
• 4-methoxyamphetamine hydrochloride
• (R,R)-Formoterol
• Formamide, N-[2-(4-methoxyphenyl)-1-methylethyl]-