2-Hydroxybenzyl alcohol Chemical Properties

Melting point:

83-85 °C(lit.)

Boiling point:

190.92°C (rough estimate)

Density 

1,613 g/cm³

refractive index 

1.5035 (estimate)

storage temp. 

Store below +30°C.

solubility 

ethanol: soluble5%, clear to very slightly hazy, colorless to light yellow

pka

pK1:9.92 (25°C)

form 

Crystalline Flakes or Powder

color 

Light beige

Water Solubility 

67 g/L (22 ºC)

Merck 

14,8325

BRN 

1907195

Stability:

Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents.

LogP

0.730

CAS DataBase Reference

90-01-7(CAS DataBase Reference)

NIST Chemistry Reference

Salicyl alcohol(90-01-7)

EPA Substance Registry System

2-Hydroxybenzenemethanol (90-01-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

DO6430000

TSCA 

Yes

HS Code 

29072900

MSDS

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2-Hydroxybenzyl alcohol Usage And Synthesis

Chemical Properties

light brown crystalline powder

Chemical Properties

Salicyl alcohol: (saligenin, o-hydroxy benzyl alcohol) crystallizes from water in the form of needles or white rhombic crystals. It occurs in nature as the bitter glycoside, salicin CAS: 138-52-3, which is isolated from the bark of Salix helix, S. pentandra, S. praecos, some other species of willow trees, and the bark of a number of species of poplar trees such as Polpulus balsamifera, P. candicans, and P. nigra.

Uses

anesthetic (local), antiinflammatory

Uses

2-Hydroxybenzyl Alcohol is a phenolic component of a part of a salix bark extract which maintains a minor anti-depressant effect. Phenolic analog with potential for anti-melanomic effect. Also It is an intermediate in the production of phenol formaldehyde res ins (may remain after condensation of the resin); sensitizer in phenol-formaldehyde resins; in loeal anesthetics.

Definition

ChEBI: A hydroxybenzyl alcohol that is phenol substituted by a hydroxymethyl group at C-2.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 5314, 1995 DOI: 10.1021/jo00121a060
Tetrahedron Letters, 10, p. 1739, 1969

General Description

2-Hydroxybenzyl alcohol participates in the selective ring opening reaction of 4H-1,3,2-benzodioxasilines.

Contact allergens

Methylol phenols are sensitizers contained in resins based on phenol and formaldehyde of the resol type. Cross-reactivity is possible with other phenol derivative molecules.

Purification Methods

Crystallise saligenine from water or EtOH/*C6H6 (m 89o). [Beilstein 6 III 4537, 6 IV 5896.]

2-Hydroxybenzyl alcohol(90-01-7)Related Product Information

• Ethyl acetate
• 2-Hydroxyphenylacetic acid
• D-(-)-Salicin
• Benzyl alcohol
• 2-Nitrobenzyl alcohol
• Sodium salicylate
• 2-Cyanophenol
• 3,5-Dihydroxybenzyl alcohol
• Salicylaldoxime
• Salicylic acid
• Benzhydrol
• Sodium 4-aminosalicylate dihydrate
• ALPHA-NAPHTHOLBENZEIN
• Salicylaldehyde
• 3-Hydroxybenzyl Alcohol 98%
• 4-HYDROXYBENZYL ALCOHOL 98+%,4-HYDROXYBENZYL ALCOHOL 99%,P-HYDROXYBENZYL ALCOHOL
• 6-CHLORO-2-HYDROXYBENZYL ALCOHOL
• 3,5-di-t-Butyl-4-hydroxybenzyl alcohol