WEHI-345
WEHI-345 Basic information
- Product Name:
- WEHI-345
- Synonyms:
-
- WEHI-345
- N-[2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-4-pyridinecarboxamide
- CS-2140
- WHI-345
- WEHI345;WEHI 345
- 4-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-
- N-(2-(4-amino-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylpropyl)isonicotinamide
- CAS:
- 1354825-58-3
- MF:
- C22H23N7O
- MW:
- 401.46
- Mol File:
- 1354825-58-3.mol
More
Less
WEHI-345 Chemical Properties
- Boiling point:
- 709.0±60.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:13.5(Max Conc. mg/mL);33.63(Max Conc. mM)
DMF:2.0(Max Conc. mg/mL);4.98(Max Conc. mM) - form
- A crystalline solid
- pka
- 12.41±0.46(Predicted)
- color
- White to off-white
More
Less
WEHI-345 Usage And Synthesis
Uses
WEHI-345 is a potent and elective inhibitor of RIPK2.
in vivo
WEHI-345 (20 mg/kg; intraperitoneal injection; twice daily; for 6 days; C57BL/6 male mice) treatment reduces disease score, inflammatory infiltrate, histological score and recruitment of dendritic cells to the site of inflammation. And improves body weight and reduces cytokine and chemokine levels, indicating an overall improvement of the condition in experimental autoimmune encephalomyelitis (EAE)-induced wild-type C57Bl/6 mice[1].
| Animal Model: | C57BL/6 male mice (8-week-old)[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; twice daily; for 6 days |
| Result: | Reduced disease score, inflammatory infiltrate, histological score and recruitment of dendritic cells to the site of inflammation. And improved body weight and reduced cytokine and chemokine levels. |
IC 50
RIPK2
WEHI-345Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com