DMT-2'-F-dGiBu
DMT-2'-F-dGiBu Basic information
- Product Name:
- DMT-2'-F-dGiBu
- Synonyms:
-
- DMT-2'-F-dGiBu
- N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
- 5'-DMT-2'-F-ibu-dG
- 5-O-DMT-N2-ISOBUTYRYL-2-FLUORO-2-DEOXYGUANOSINE
- 5'-DMT-2'-F-ibu-dG 144089-96-3
- Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)-
- 5'-O-DMT-N2-ibu-2'-F-dG
- N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-3H-purin-2-yl)isobutyramide
- CAS:
- 144089-96-3
- MF:
- C35H36FN5O7
- MW:
- 657.69
- Product Categories:
-
- Modified（deoxy）nucleoside
- Mol File:
- 144089-96-3.mol
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DMT-2'-F-dGiBu Chemical Properties
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.16±0.20(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- QQQXVSXVBFQISZ-SEXLECIHNA-N
- SMILES
- C(NC1=NC(=O)C2=C(N1)N([C@H]1[C@H](F)[C@H](O)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C(C)C |&1:10,11,13,15,r|
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DMT-2'-F-dGiBu Usage And Synthesis
Uses
DMT-2'-F-iBu-G (5'-DMT-2'-F-ibu-dG) is a modified oligonucleotide. 2'-deoxy-2'-fluoro-modified oligonucleotides shows high nuclease resistant and retained exceptional binding affinity to the RNA targets[1].
Definition
DMT-2'-F-dGiBu is a raw material for RNA phosphoramidites.
References
[1] Kawasaki AM, et al. Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem. 1993 Apr 2;36(7):831-41. DOI:10.1021/jm00059a007
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