3,4-Dibromo-Mal-PEG2-Boc-Amine Chemical Properties

Boiling point:

513.0±50.0 °C(Predicted)

Density 

1.609±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Solid

pka

12.23±0.46(Predicted)

color 

White to off-white

3,4-Dibromo-Mal-PEG2-Boc-Amine Usage And Synthesis

Description

3,4-Dibromo-Mal-PEG2-Boc-Amine is a hydrophilic PEG species containing a dibromomaleimide group and a Boc-protected amine. The dibromomaleimide group allows for two points of attachement because both of the bromine atoms can be substituted. The Boc protecting group can be removed under acidic conditions and allows for the amine to further react with other species. The hydrophilic PEG linker increases the compound's water solubility properties in aqueous media.

Uses

3,4-Dibromo-Mal-PEG2-N-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

3,4-Dibromo-Mal-PEG2-Boc-Amine(1807537-43-4)Related Product Information

• 3,4-Dibromo-Mal-PEG4-t-butyl ester
• 3,4-Dibromo-Mal-PEG2-Amine