Ald-PEG3-Azide
Ald-PEG3-Azide Basic information
- Product Name:
- Ald-PEG3-Azide
- Synonyms:
-
- Ald-PEG3-Azide
- ALD-CH2-PEG3-AZIDE
- Ald-CH2-PEG3-N3
- CHO-PEG3-azide
- N3-PEG3-CH2CHO
- CAS:
- 1002342-83-7
- MF:
- C8H15N3O4
- MW:
- 217.23
- Product Categories:
-
- peg
- Mol File:
- 1002342-83-7.mol
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Ald-PEG3-Azide Chemical Properties
- solubility
- Soluble in Water, DMSO, DMF, DCM
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Ald-PEG3-Azide Usage And Synthesis
Description
Ald-CH2-PEG3-azide is a click chemistry PEG linker. Aldehyde groups are likely to undergo nucleophile substitution, reduction and oxidation reactions. The azideN3 enable Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. PEG3 spacer increases the water solubility of the compound.
Biological Activity
Ald-CH2-PEG3-azide is a cleavable 3-unit PEG-containing ADC linker that can be used to synthesize antibody drug conjugates (ADCs),it is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|