Azido-PEG4-CH2CO2H Chemical Properties

Boiling point:

375.0±32.0 °C(Predicted)

Density 

1.151±0.06 g/cm3(Predicted)

storage temp. 

Store at 0-8 °C

pka

3.39±0.10(Predicted)

form 

Liquid

color 

Light yellow to yellow

InChI

InChI=1S/C11H18O6/c1-2-3-14-4-5-15-6-7-16-8-9-17-10-11(12)13/h1H,3-10H2,(H,12,13)

InChIKey

MJRNNISHHNMYAE-UHFFFAOYSA-N

SMILES

C(O)(=O)COCCOCCOCCOCC#C

Safety Information

HS Code 

2918999090

Azido-PEG4-CH2CO2H Usage And Synthesis

Description

Propargyl-PEG4-CH2CO2H is a linker consisting of a propargyl group with a carboxylic acid group. The carboxylic acid can react with primary amine groups in the presence of activators such as HATU or EDC. The propargyl group can react with azide compounds in Click Chemistry; copper catalyst will be needed. The PEG units help the molecule to have better solubility in aqueous solution.

Uses

Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781

Azido-PEG4-CH2CO2H(1694731-93-5)Related Product Information

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