m-PEG4-aldehyde
m-PEG4-aldehyde Basic information
- Product Name:
- m-PEG4-aldehyde
- Synonyms:
-
- mPEG3-propionaldehyde
- m-PEG4-aldehyde
- MPEG4-ALD
- mPEG4-CHO
- MPEG4-CH2CH2CHO
- mPEG4-pAld
- 2,5,8,11-Tetraoxatetradecan-14-al
- 4,7,10,13-Tetraoxatetradecanal
- CAS:
- 197513-96-5
- MF:
- C10H20O5
- MW:
- 220.26
- Mol File:
- 197513-96-5.mol
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m-PEG4-aldehyde Chemical Properties
- Boiling point:
- 296.0±25.0 °C(Predicted)
- Density
- 1.017±0.06 g/cm3(Predicted)
- form
- Liquid (Density: 1.017±0.06 g/cm3)
- color
- Colorless to light yellow
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m-PEG4-aldehyde Usage And Synthesis
Description
m-PEG4-aldehyde is a aldehyde linker that is reactive to hydrazide and aminooxy groups for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG4 spacer increases solubility in aqueous media.
Uses
m-PEG4-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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