Tos-PEG2-CH2CO2tBu Chemical Properties

Boiling point:

449.0±30.0 °C(Predicted)

Density 

1.183±0.06 g/cm3(Predicted)

storage temp. 

Store at Room Tem.

Appearance

colorless liquid

Tos-PEG2-CH2CO2tBu Usage And Synthesis

Description

Tos-PEG2-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6

Tos-PEG2-CH2CO2tBu(1643957-24-7)Related Product Information

• Tos-PEG4-acid
• Tos-PEG5 t-butyl ester
• Tos-PEG2-t-butyl ester
• Tos-PEG4-CH2CO2H
• Tos-PEG4-t-butyl ester
• Tos-PEG6-t-Butyl ester
• Tos-PEG3-CH2CO2tBu
• Tos-PEG5-CH2CO2H
• Tos-PEG5-CH2CO2t-butyl ester
• Tos-PEG3-CH2CO2H