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Cilazapril

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Cilazapril Basic information

Product Name:
Cilazapril
Synonyms:
  • 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-
  • 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-
  • Ro 31-2848
  • Yipingshu
  • CILASTATIN NA
  • CILASTATIN SODIUM SALT
  • sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate
  • (1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
CAS:
88768-40-5
MF:
C22H31N3O5
MW:
417.5
EINECS:
641-006-9
Product Categories:
  • Chiral Reagents
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
88768-40-5.mol
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Cilazapril Chemical Properties

Melting point:
95-97°C
Boiling point:
598.1±60.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form 
powder
pka
2.28±0.20(Predicted)
color 
White to Off-White
CAS DataBase Reference
88768-40-5(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
MJ9650200
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Cilazapril Usage And Synthesis

Description

Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.

Chemical Properties

Off-White Solid

Uses

An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.

Definition

ChEBI: Cilazapril is a pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is an ethyl ester, a pyridazinodiazepine and a dicarboxylic acid monoester. It is functionally related to a Cilazaprilat.

brand name

Inhibace (Hoffmann-LaRoche).

CilazaprilSupplier

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021-58955995
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