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Cilazapril

Basic information Safety Supplier Related

Cilazapril Basic information

Product Name:
Cilazapril
Synonyms:
  • 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-
  • 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-
  • Ro 31-2848
  • Yipingshu
  • CILASTATIN NA
  • CILASTATIN SODIUM SALT
  • sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate
  • (1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
CAS:
88768-40-5
MF:
C22H31N3O5
MW:
417.5
EINECS:
641-006-9
Product Categories:
  • Chiral Reagents
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
88768-40-5.mol
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Cilazapril Chemical Properties

Melting point:
95-97°C
storage temp. 
2-8°C
form 
powder
CAS DataBase Reference
88768-40-5(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
MJ9650200
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Cilazapril Usage And Synthesis

Description

Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.

Chemical Properties

Off-White Solid

Uses

An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive

Uses

An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.

brand name

Inhibace (Hoffmann-LaRoche).

CilazaprilSupplier

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