GLYCOLALDEHYDE Chemical Properties

Melting point:

97°C

Boiling point:

35.05°C (rough estimate)

Density 

1.3660

refractive index 

1.4772

pka

13.34±0.10(Predicted)

LogP

-1.604 (est)

EPA Substance Registry System

Acetaldehyde, hydroxy- (141-46-8)

GLYCOLALDEHYDE Usage And Synthesis

Uses

Glycolaldehyde is derived from 2,2-Diethoxyethanol (D441940), which is used in the synthesis of neooxazolomycin, part of the oxazolomycin family of antibiotics. Also used in the synthesis of pyrimidine based inhibitors of phosphodiesterase 7 (PDE7).

Definition

ChEBI: The glycolaldehyde derived from ethylene glycol. The parent of the class of glycolaldehydes.

Hazard

Moderately toxic by ingestion

Synthesis

Glycolaldehyde was prepared as follows: formaldehyde (30 mmol) was placed in a reactor, then N,N-dimethylformamide (10 ml) was added to the reactor, amidine catalyst I-K (0.15 mmol, as shown in FIG. 2) or silica gel solid-loaded triazole catalyst A-H (1 g, 0.15 mmol triazole salt/g of the carrier, as shown in FIG. 2), and the additive triethylamine ( 0.70 mmol). The reactor was installed and the reaction was stirred at a temperature of 0-300??C and a pressure of 0-10 MPa for 1-1000 min.

GLYCOLALDEHYDE(141-46-8)Related Product Information

• 2,3-Dimethoxy-5-methyl-p-benzoquinone
• Diethyl squarate
• 4-CHLOROPHENOXYACETYL CHLORIDE
• 2-Acetoxy-2-phenylacetyl chloride
• Squaric acid
• Ethyl bromopyruvate
• Colchicine
• Chloranilic acid
• 1-Chlorocarbonyl-1-methylethyl acetate
• RHODIZONIC ACID DIPOTASSIUM SALT
• Phenoxyacetyl chloride
• Ethyl oxalyl monochloride
• 2,5-DIHYDROXY-1,4-BENZOQUINONE
• Clofibrate
• Tetrahydroxyquinone
• (-)-MENTHOXYACETIC ACID
• GLYCOLALDEHYDE DIETHYL ACETAL
• Methoxyacetyl chloride