HEPPS
HEPPS Basic information
- Product Name:
- HEPPS
- Synonyms:
-
- HEPPS(EPPS)
- 4-(2-Hydroxyethyl)pi
- HEPE
- 3-[4-(2-HYDROXYETHYL)-1-PIPERAZINE]PROPANESULFONIC ACID
- 3-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]PROPANESULFONIC ACID
- N-(2-HYDROXYETHYL)-N'-(3-SULFOPROPYL)-PIPERAZINE
- N-[2-HYDROXYETHYL]PIPERAZINE-N'-[3-PROPANESULFONIC ACID]
- N-2-HYDROXYETHYLPIPERAZINE-N'-3-PROPANESULPHONIC ACID
- CAS:
- 16052-06-5
- MF:
- C9H20N2O4S
- MW:
- 252.33
- EINECS:
- 240-198-8
- Product Categories:
-
- Pharmaceutical Intermediates
- Miscellaneous Biochemicals
- Biochemistry
- Good's Buffers
- buffer
- Mol File:
- 16052-06-5.mol
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HEPPS Chemical Properties
- Melting point:
- 237-239 °C(lit.)
- Density
- 1.2684 (rough estimate)
- refractive index
- 1.6800 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- H2O: 1 M at 20 °C, clear, colorless
- form
- Powder/Solid
- color
- White
- PH Range
- 7.3 - 8.7
- PH
- 5.0-6.5 (25℃, 0.1M in H2O)
- pka
- 8.0(at 25℃)
- Water Solubility
- Soluble in water. 25.2 g/L (20°C)
- λmax
- λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.045 - BRN
- 3957385
- CAS DataBase Reference
- 16052-06-5(CAS DataBase Reference)
- EPA Substance Registry System
- 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)- (16052-06-5)
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Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 24/25-36-26
- WGK Germany
- 3
- RTECS
- TM2649130
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29335995
- Toxicity
- quail,LD50,oral,> 316mg/kg (316mg/kg),Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
MSDS
- Language:English Provider:4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
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HEPPS Usage And Synthesis
Chemical Properties
white crystalline powder
Uses
HEPPS (EPPS) is a commonly used Good's buffer. It is often used as separator in ultrathin isoelectric focusing gels and enhances the resolution of phosphoglucomutase. It is used as a buffering agent in biology and biochemistry. HEPPS is a biological buffer with a useful pH range of 7.3-8.7 and a pKa=8.0 at 25°C. Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.
Definition
ChEBI: HEPPS is a N-(sulfoalkyl)piperazine and a N-(2-hydroxyethyl)piperazine.
Flammability and Explosibility
Not classified
HEPPSSupplier
Smart & Happy Biotech Co.,Ltd. Gold
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- 13395193426
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- 18971041571
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- 0185-0185-07139096 18507139096
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Suzhou Genemill Biotechnology Co.,Ltd Gold
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- 0512-65917170 17766001019;
- xiely@genemill.com
Shanghai Yikefan Biotechnology Co., LTD Gold
- Tel
- 18221419461; 18221419461
- sales@yikefan.com
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HEPPS(16052-06-5)Related Product Information
- 1-Ethylpiperazine
- Folic acid
- Calcium dobesilate
- 2-(METHYLSULFONYL)ETHANOL
- Citric acid
- 2-Hydroxyethanesulphonic acid
- Sodium ethylenesulphonate
- 2-Ethylpiperazine
- Hydroxyethyl Cellulose
- Piperazine
- HEPES
- Sodium isethionate
- Hydroxyethyl starch
- 2-Piperidinoethanol
- N-Aminoethylpiperazine
- 1-(2-Hydroxyethyl)piperazine
- Ascoric Acid
- HEPPSO