Methyl levulinate Chemical Properties

Melting point:

237 °C

Boiling point:

193-195 °C (lit.)

Density 

1.051 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.422

FEMA 

4478 | METHYL LEVULINATE

Flash point:

72°C

storage temp. 

Refrigerator

solubility 

It is soluble in ethanol, ether, acetone and benzene.

form 

Liquid

Specific Gravity

1.05

color 

Clear Colourless

Odor

caramellic

Odor Type

caramellic

JECFA Number

1970

BRN 

1754008

InChI

1S/C6H10O3/c1-5(7)3-4-6(8)9-2/h3-4H2,1-2H3

InChIKey

UAGJVSRUFNSIHR-UHFFFAOYSA-N

SMILES

COC(=O)CCC(C)=O

LogP

-0.13

Surface tension

36mN/m at 293.15K

CAS DataBase Reference

624-45-3(CAS DataBase Reference)

NIST Chemistry Reference

Pentanoic acid, 4-oxo-, methyl ester(624-45-3)

Safety Information

Safety Statements 

23-24/25

WGK Germany 

3

HS Code 

29183000

Storage Class

10 - Combustible liquids

MSDS

• Language:English Provider:Methyl levulinate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl levulinate Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Methyl levulinate is mainly used as raw material on perfume.

Definition

ChEBI: Methyl levulinate is an oxo carboxylic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 2624, 1948 DOI: 10.1021/ja01188a004
Tetrahedron, 42, p. 4247, 1986 DOI: 10.1016/S0040-4020(01)87649-3
Synthetic Communications, 13, p. 509, 1983 DOI: 10.1080/00397918308081830

General Description

Methyl levulinate can be synthesized from glucose in the presence of a few drops of dilute sulfuric acid in methanol.

Synthesis

The acid was converted to the ester by boiling in methanol (0.5 M solution) in the presence of concentrated sulfuric acid (500 ??L). The reaction was followed by TLC (heptane/EtOAc 2:1). When only trace amounts of acid remained, the reaction mixture was cooled, concentrated, diluted with NaHCO3 solution, extracted with DCM, dried with MgSO4 and concentrated to give the end product methyl acetylpropionate.

Methyl levulinate(624-45-3)Related Product Information

• DIETHYL ACETYLSUCCINATE
• Ethyl levulinate
• Butyl levulinate
• Dimethyl acetylsuccinate
• Levulinic acid
• Propyl Levulinate
• Acetylacetone
• Diethyl acetylmalonate
• Nickel(II) acetylacetonate
• Chromium(III) acetylacetonate
• Cupric acetylacetonate
• Ferric acetylacetonate
• CALCIUM LEVULINATE
• AC-LYS-OH
• AC-TRP-OME
• N-Acetyl-L-histidine
• sodium 4-oxovalerate
• Benzyl Acetoacetate