Sacubitril Impurity Chemical Properties

Boiling point:

595.6±50.0 °C(Predicted)

Density 

1.132±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

4.67±0.19(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C23H27NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-14,20H,15H2,1-4H3,(H,24,27)(H,25,26)/b16-14+/t20-/m1/s1

InChIKey

JXTNUXJSXXIIFE-KETLNSEPSA-N

SMILES

C(O)(=O)/C(/C)=C/[C@@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

Sacubitril Impurity Usage And Synthesis

Uses

(2E,4S)-5-[1,1''-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid was used in the study to process for preparation of biaryl-substituted 4-aminobutyric acids by hydrogenation of the corresponding alkenoates.

Sacubitril Impurity(1015037-46-3)Related Product Information

• Sacubitril Impurity 19
• (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride
• ahu377 isomer 2
• LCZ Impurity
• (2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
• LCZ696 InteMediate
• sacubitril
• AHU-377
• Sacubitril Impurity 31
• Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate
• 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-
• Sacubitril Impurity 14
• Sacubitril impurity 030
• Sacubitril Impurity 17
• Sacubitril Impurity 15
• Sacubitril Impurity 20
• Sacubitril Impurity 13
• Sacubitril Impurity 16