Siremadlin
Siremadlin Basic information
- Product Name:
- Siremadlin
- Synonyms:
-
- (6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one
- HDM-201
- NVP-HDM201
- CS-2613
- CS-2787
- HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201
- (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
- Siremadlin
- CAS:
- 1448867-41-1
- MF:
- C26H24Cl2N6O4
- MW:
- 555.41
- Mol File:
- 1448867-41-1.mol
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Siremadlin Chemical Properties
- Boiling point:
- 736.5±70.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 56.75 mg/mL (102.18 mM)
- form
- Solid
- pka
- 1.33±0.29(Predicted)
- color
- White to off-white
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Siremadlin Usage And Synthesis
Uses
Siremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies. the safety profile of Siremadlin did not differ significantly between tumor types and treatment regimens.
SiremadlinSupplier
ShangHai ChuanQian Chemcial Technique Centre Gold
- Tel
- 15869524721
- 3525679403@qq.com
Shanghai Boyle Chemical Co., Ltd.
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- sales@boylechem.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
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- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
Shanghai YuanQi Biotechnology Co., Ltd.
- Tel
- +86-2332782371 +86-18120098618
- sales@adobechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266