(2-BROMOBENZYL)METHYLAMINE Chemical Properties

Boiling point:

71-74 °C2 mm Hg(lit.)

Density 

1.358 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.5670(lit.)

Flash point:

220 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Viscous Liquid

pka

9.14±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Sensitive 

Air Sensitive

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

2

HazardClass 

8

MSDS

• Language:English Provider:SigmaAldrich

(2-BROMOBENZYL)METHYLAMINE Usage And Synthesis

Synthesis

Preparation of Example (Compound 22a): 29.4 g of o-bromobenzaldehyde and 81 mL of 40% aqueous methylamine were mixed with 238 mL of tetrahydrofuran (THF). At room temperature, 19 g of sodium borohydride (NaBH4) was added in batches over 25 minutes. The reaction mixture was stirred overnight at room temperature and then concentrated using a rotary evaporator. The residue was stirred into ice water and the aqueous phase was extracted twice with ether. The combined ether phases were concentrated by evaporation under reduced pressure. The product was purified by silica gel column chromatography using ethyl acetate or ethyl acetate/methanol (4:1) as eluent to give 18.5 g of N-methyl-2-bromobenzylamine (22a) in yellow liquid form. Yield: 58%.

References

[1] Patent: US6232468, 2001, B1
[2] Tetrahedron, 2003, vol. 59, # 40, p. 8049 - 8056

(2-BROMOBENZYL)METHYLAMINE(698-19-1)Related Product Information

• 2-BROMO-N-METHYLBENZAMIDE
• 2-bromo-N,N-dimethylbenzylamine
• 2-Bromo-N-(2,6-dimethylphenyl)benzamide
• BRETYLIUM TOSYLATE
• N-BENZYL 2-BROMOBENZAMIDE
• 3,4,5,6-TETRABROMOPHTHALIMIDE
• (4-Bromobenzyl)methylamine95%,(4-BROMOBENZYL)METHYLAMINE
• (3-BROMOBENZYL)METHYLAMINE,(3-Bromobenzyl)methylamine95%
• 2-BROMOBENZYLAMINE
• N-(2-CHLOROETHYL)-N-ETHYL-2-BROMOBENZYLAMINE HYDROCHLORIDE
• methyl [(2-bromobenzoyl)amino]acetate
• N-[(6-BROMO-1,3-BENZODIOXOL-5-YL)METHYL]-2,4-DIFLUOROANILINE
• 2-bromo-N-(2-iodophenyl)benzamide
• AURORA 11333
• 2-bromo-N-(4-hydroxyphenyl)-N-methylbenzamide
• 2-(2-bromophenyl)-1,3-thiazolidine-4-carboxylic acid
• 2-bromo-N-(3-methylphenyl)benzamide
• 2-bromo-N-(2,4-dichlorophenyl)benzamide