LY-3177833 Chemical Properties

Boiling point:

660.7±55.0 °C(Predicted)

Density 

1.398±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:30.0(Max Conc. mg/mL);96.99(Max Conc. mM)

form 

A crystalline solid

pka

11.67±0.40(Predicted)

color 

White to off-white

LY-3177833 Usage And Synthesis

Description

LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC₅₀ = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC₅₀ = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day.

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