LY-3177833 Chemical Properties

Boiling point:

660.7±55.0 °C(Predicted)

Density 

1.398±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:30.0(Max Conc. mg/mL);96.99(Max Conc. mM)

form 

A crystalline solid

pka

11.67±0.40(Predicted)

LY-3177833 Usage And Synthesis

Description

LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC₅₀ = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC₅₀ = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day.

LY-3177833(1627696-51-8)Related Product Information

• LY2090314
• LY 2874455
• LY-2608204
• LY2811376
• LY 2157299
• 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol
• LY3214996
• LY2409881
• Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2
• LY3023414
• LY 294002 HYDROCHLORIDE
• LY2955303
• LY2886721
• LY-2584702 (tosylate salt)
• LY2409881 trihydrochloride
• LY-364947
• LY411575
• Abemaciclib