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Aprepitant Impurity 6

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Aprepitant Impurity 6 Basic information

Product Name:
Aprepitant Impurity 6
Synonyms:
  • Fosaprepitant Dimeglumine Impurity A
  • Aprepitant Impurity 5(S,R,S-Isomer)
  • Aprepitant impurity 9/(1S,2R,3S)-Aprepitant
  • 1S, 2R, 3S-Aripitan
  • Arepitam impurity isomers (1S, 2R, 3S)
  • 5-([(2R,3S)-2-((S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one
  • 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
  • Fosaprepitant Dimeglumine EP Impurity A
CAS:
170902-81-5
MF:
C23H21F7N4O3
MW:
534.43
Mol File:
170902-81-5.mol
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Aprepitant Impurity 6 Chemical Properties

Density 
1.51±0.1 g/cm3(Predicted)
pka
8.06±0.20(Predicted)
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Aprepitant Impurity 6 Usage And Synthesis

Uses

[1(S)-Phenylethoxy]-Aprepitant is a derivative of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.

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