Thiol-dPEG4-amie Chemical Properties

Boiling point:

309.6±32.0 °C(Predicted)

Density 

1.060±0.06 g/cm3(Predicted)

pka

9?+-.0.10(Predicted)

Thiol-dPEG4-amie Usage And Synthesis

Biological Activity

HS-PEG3-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Thiol-dPEG4-amie(1189760-69-7)Related Product Information

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• Thiol-PEG8-NH2
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• Thiol-PEG6-NH2
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