UNC3866
UNC3866 Basic information
- Product Name:
- UNC3866
- Synonyms:
-
- UNC3866
- N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester
- CS-2491
- UNC 3866;UNC-3866
- (3S,6S,9S,12S,15S)-Methyl 3-benzyl-1-(4-(tert-butyl)phenyl)-12-(4-(diethylamino)butyl)-15-(hydroxymethyl)-9-isobutyl-6-methyl-1,4,7,10,13-pentaoxo-2,5,8,11,14-pentaazahexadecan-16-oate
- L-Serine, N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-, methyl ester
- UNC3866,inhibit,Histone Methyltransferase,UNC-3866,Inhibitor,UNC 3866
- CAS:
- 1872382-47-2
- MF:
- C43H66N6O8
- MW:
- 795.02
- Mol File:
- 1872382-47-2.mol
UNC3866 Chemical Properties
- Boiling point:
- 1034.5±65.0 °C(Predicted)
- Density
- 1.129±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
- pka
- 13.39±0.46(Predicted)
- color
- White to off-white
UNC3866 Usage And Synthesis
Description
UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM). It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.
Uses
Polycomb group proteins (CBX4, CBX7) regulate cell fate decisions during embryogenesis. N-?[4-?(1,?1-Dimethylethyl)?benzoyl]?-?L-?phenylalanyl-?L-?alanyl-?L-?leucyl-?N6,?N6-?diethyl-?L-?lysyl-?L-serine Methyl Ester is a selective antagonist of CBX4 and CBX7 chromodomains. It also inhibits prostate cell proliferation.
UNC3866Supplier
- Tel
- sales@boylechem.com
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- 0510-85629785 18013409632
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- 021-52996696，15000506266 15000506266
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- 021-61350663 13052117465
- sales@zehanbiopharma.com
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- 18122150900
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