SB-756050 Chemical Properties

Boiling point:

653.1±65.0 °C(Predicted)

Density 

1.328±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml; DMSO: 10 mg/ml

form 

A crystalline solid

pka

-6.97±0.20(Predicted)

SB-756050 Usage And Synthesis

Description

SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC₅₀ = 1.3 μM for the human receptor). It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats.

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