ChemicalBook > Product Catalog > Organic Chemistry > Alcohols,Phenols,Phenol alcohols > 1-isothiocyanato-PEG4-Alcohol
1-isothiocyanato-PEG4-Alcohol
1-isothiocyanato-PEG4-Alcohol Basic information
- Product Name:
- 1-isothiocyanato-PEG4-Alcohol
- Synonyms:
-
- 1-isothiocyanato-PEG4-Alcohol
- 3,6,9-Trioxa-12-azatridec-12-en-1-ol, 13-thioxo-
- 1-Isothiocyanato PEG4-alcoho
- CAS:
- 1835759-69-7
- MF:
- C9H17NO4S
- MW:
- 235.3
- Mol File:
- 1835759-69-7.mol
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1-isothiocyanato-PEG4-Alcohol Chemical Properties
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
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1-isothiocyanato-PEG4-Alcohol Usage And Synthesis
Description
1-isothiocyanato-PEG4-Alcohol is a crosslinker containing an hydroxyl group and isothiocyanato group. The hydroxyl group can undergo different reactions to further derivatize the compound. Isothiocyanate and its linkage isomer thiocyanate are ligands in coordination chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
1-Isothiocyanato-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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