Propargyl-PEG3-Sulfone-PEG3-Propargyl Chemical Properties

Boiling point:

591.6±50.0 °C(Predicted)

Density 

1.147±0.06 g/cm3(Predicted)

Propargyl-PEG3-Sulfone-PEG3-Propargyl Usage And Synthesis

Description

Propargyl-PEG3-Sulfone-PEG3-propargyl is a PEG linker containing two propargyl groups. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Propargyl-peg3-sulfone-peg3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-peg3-sulfone-peg3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Propargyl-PEG3-Sulfone-PEG3-Propargyl(2055024-44-5)Related Product Information

• Propargyl-PEG3-methyl ester
• Propargyl-PEG3-phosphonic acid ethyl ester
• Propargyl-PEG3-Bromide
• Propargyl--PEG3-phosphonic acid
• Propargyl-PEG4-5-nitrophenyl carbonate
• Propargyl-PEG3-t-butyl ester
• Propargyl-PEG3-NH2
• Propargyl-PEG4-(CH2)3-acid
• Propargyl-PEG4-(CH2)3-methyl ester
• Propargyl-PEG3-Ms
• Propargyl-PEG4-S-PEG4-t-butyl ester
• Propargyl-PEG4-S-PEG4-Propargyl
• Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
• Propargyl-PEG4-S-PEG4-acid
• Propargyl-PEG4-Sulfone-PEG4-acid
• Propargyl-PEG5-tetra-Ac-beta-D-galactose
• Propargyl-PEG1-SS-PEG1-PFP ester
• Propargyl-PEG1-SS-alcohol