S-acetyl-PEG4-Propargyl Chemical Properties

Boiling point:

375.6±37.0 °C(Predicted)

Density 

1.102±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DMSO, DCM, DMF

form 

clear liquid

color 

Yellow to Amber to Dark red

Safety Information

HS Code 

2923.90.0100

S-acetyl-PEG4-Propargyl Usage And Synthesis

Description

S-acetyl-PEG4-propargyl is a PEG linker containing a sulfur acetyl group and a propargyl moiety. The sulfur acetyl group can be deprotected to produce a thiol compound. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG linker increases the water solubility of the compounds in the aqueous media.

Uses

S-acetyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

S-acetyl-PEG4-Propargyl(1422540-88-2)Related Product Information

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