Tri(Amino-PEG3-amide)-amine Chemical Properties

Boiling point:

910.3±65.0 °C(Predicted)

Density 

1.134±0.06 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

Oil

pka

15.11±0.46(Predicted)

color 

Light yellow to yellow

Tri(Amino-PEG3-amide)-amine Usage And Synthesis

Description

Tri(Amino-PEG3-amide)-amine is a water soluble PEG linker containing three amino groups. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

Tri(Amino-PEG3-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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