ML385 Chemical Properties

Density 

1.374±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:31.4(Max Conc. mg/mL);61.38(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.64(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.49(Max Conc. mM)

form 

powder

pka

8.92±0.50(Predicted)

color 

white to beige

InChIKey

LINHYWKZVCNAMQ-UHFFFAOYSA-N

SMILES

O1C2=CC=C(CC(NC3=NC(C4C=CC5=C(C=4)CCN5C(=O)C4=CC=CC=C4C)=C(C)S3)=O)C=C2OC1

ML385 Usage And Synthesis

Biochem/physiol Actions

ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.

storage

Store at -20°C

ML385(846557-71-9)Related Product Information

• ML188
• ML418
• [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
• ML213
• N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
• PTP1B-IN-2
• ML264
• ML216
• ML365
• ML 141
• ML355
• M348
• ml390
• (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
• 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
• ML277
• ML364
• VU0456810