2-Acetylpyrene Chemical Properties

Melting point:

141-142 °C

Boiling point:

437.7±14.0 °C(Predicted)

Density 

1.262±0.06 g/cm3(Predicted)

2-Acetylpyrene Usage And Synthesis

Application

2-Acetylpyrene can be used as a pharmaceutical synthesis intermediate.

Synthesis

The synthesis of 2-Acetylpyrene method is as follows: Stir a solution of 2-acetyl-4,5,9,10-tetrahydropyrene (2.01 mmol) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (2.1 equivalents, 0.96 g, 4.23 mmol) in dry THF (25 mL) at reflux (80 °C) under a stream of N2 for 2 days. Remove the solvent by rotary evaporation under reduced pressure. Wash the remaining residue with 5% aqueous KOH (15 mL). Extract the residue with DCM (3 × 30 mL). Dry the combined extracts over MgSO4. Filter the residue. Evaporate the filtrate to dryness. Purify the product by column chromatography (silica gel, ethyl acetate:n-hexane 1:9). Crystallize the crude product from EtOH.¹

References

[1] LÍLIA I.L. CABRAL . Synthesis and structure of 2-substituted pyrene-derived scaffolds[J]. Tetrahedron Letters, 2017, 58 48: Pages 4547-4550. DOI:10.1016/j.tetlet.2017.10.058.

2-Acetylpyrene(789-06-0)Related Product Information

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