Basic information Safety Supplier Related

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

Basic information Safety Supplier Related

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Basic information

Product Name:
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
Synonyms:
  • 7-ALPHA-HYDROXYCHOLESTEROL
  • 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
  • cholest-5-en-3 beta,7 alpha-diol
  • (3,7a)-Cholest-5-ene-3,7-diol
  • 7a-Hydroxycholest-5-en-3ol
  • 3β,7α-Dihydroxycholest-5-ene
  • 7alpha-Cholesterol
  • Cholest-5-ene-3,7-diol, (3beta,7alpha)-
CAS:
566-26-7
MF:
C27H46O2
MW:
402.66
Product Categories:
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids
Mol File:
566-26-7.mol
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5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Chemical Properties

Melting point:
168-170°C
Boiling point:
515.3±38.0 °C(Predicted)
Density 
1.03±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Soluble in DMSO or in Ethanol.
form 
solid
pka
14.11±0.70(Predicted)
color 
White or pale yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Usage And Synthesis

Description

7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4

Chemical Properties

White Solid

Uses

Secondary metabolite of Cholesterol.

Definition

ChEBI: The 7alpha-hydroxy derivative of cholesterol.

References

1) Duane and Javitt (2002),?Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med.,?139?109 2) Kim?et al.?(2015)?7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun.,?467?879 3) Kim?et al.?(2014)?27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol.,?274?462 4) Saito and Noguchi (2014)?7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun.,?446?741

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOLSupplier

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