2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE Chemical Properties

Melting point:

58-61°C

Boiling point:

352.0±45.0 °C(Predicted)

Density 

1.267±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DCM, Ethyl Acetate, Methanol

pka

1.73±0.29(Predicted)

form 

Solid

color 

White

Safety Information

HS Code 

2933998090

2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE Usage And Synthesis

Uses

5-Bromo-2,4-bis(1,1-dimethylethoxy)pyrimidine is an intermediate in the synthesis of β-Pseudouridine (O839607), an isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA.

Synthesis

5-Bromo-2,4-dichloropyrimidine (10.0 mmol, 2.28 g) is dissolved in dry THF (50 mL). Then a solution of sodium tert-butoxide (25.0 mmol, 2.40 g) in THF (100 mL) is added dropwise at rt and the reaction mixture stirred for 5 h. The reaction is quenched with water (50 mL) and extracted with EtOAc (3 x 50 mL). Purification by flash chromatography yielded the desired product 5 as colorless solid (2.79 g, 92%). 5-Bromo-2,4-di-tert-butoxypyrimidine 5 ,Yield 2.79 g, 92%.

2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE(19752-61-5)Related Product Information

• 5-Bromopyrimidine
• 2,4-DIETHOXYPYRIMIDINE
• 5-BROMO-2-(TERT-BUTOXY)PYRIMIDINE
• 5-Bromo-2-methoxypyrimidine
• 5-bromo-1H-pyrimidin-4-one
• 5-BROMO-2,4-DIMETHOXYPYRIMIDINE
• 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE
• 5-BROMO-2-HYDROXYPYRIMIDINE
• 5-BROMO-2-ETHOXY-PYRIMIDINE