3-Fluorobenzyl alcohol Chemical Properties

Melting point:

115-119 °C

Boiling point:

104-105 °C/22 mmHg (lit.)

Density 

1.164 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.513(lit.)

Flash point:

195 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

14.09±0.10(Predicted)

form 

Liquid

Specific Gravity

1.164

color 

Clear colorless

BRN 

2242511

CAS DataBase Reference

456-47-3(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanol, 3-fluoro-(456-47-3)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

14-34-36/37

Safety Statements 

24/25-45-36/37/39-27-26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29062900

MSDS

• Language:English Provider:3-Fluorobenzyl alcohol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Fluorobenzyl alcohol Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

3-Fluorobenzyl alcohol was used as substrate to study pH dependence of aryl-alcohol oxidase activity.

Definition

ChEBI: 3-fluorobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted by a fluoro group at position 3. It is a member of monofluorobenzenes and a member of benzyl alcohols.

General Description

3-Fluorobenzyl alcohol undergoes acetylation reaction with acetic anhydride catalyzed by tribromo melamine to yield 3-fluorobenzyl acetate.

Synthesis

GENERAL STEPS: Prior to use, 0.05 g of 5 wt% Pt/C catalyst was pretreated in a stream of hydrogen at 673 K for 2 hours. Subsequently, the pretreated catalyst was mixed with 20 mL of solvent (e.g., ethanol) and the mixture was transferred to a 100 mL high-pressure reactor. After filling the reactor with hydrogen at 4.0 MPa, the reaction was initiated and hydrogenation was carried out at a set temperature. The reaction was terminated after reaching a predetermined time, and the products were analyzed by a gas chromatograph (GC-2014, Shimadzu Co.) equipped with a capillary column (DM-WAX, 30 m × 0.32 mm × 0.25 μm) coupled with a flame ionization detector (FID).

References

[1] Tetrahedron Letters, 1991, vol. 32, # 9, p. 1199 - 1202
[2] Organic Letters, 2007, vol. 9, # 15, p. 2791 - 2793
[3] Tetrahedron, 2008, vol. 64, # 51, p. 11783 - 11788
[4] Advanced Synthesis and Catalysis, 2014, vol. 356, # 5, p. 1093 - 1097
[5] Organic Letters, 2007, vol. 9, # 26, p. 5429 - 5432

3-Fluorobenzyl alcohol(456-47-3)Related Product Information

• Benzyl alcohol
• Ethyl acetate
• Transfluthrin
• 4-Nitrobenzyl alcohol
• [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate
• Florfenicol
• 2-(Trifluoromethyl)benzyl chloride
• 4-Fluorobenzaldehyde
• alpha-Chloro-o-fluorotoluene
• Haloperidol
• 4-AMINO-2,3,5,6-TETRAFLUOROBENZOIC ACID
• Pentafluorobenzoic acid
• 2,3,5,6-Tetrafluorobenzoic acid
• 3-Fluorobenzoic acid
• 2,3,6-TRIFLUOROBENZOIC ACID
• 1-(PENTAFLUOROPHENYL)ETHANOL
• 2,3,4,5,6-Pentafluorobenzyl alcohol
• ETHYL 3-FLUOROBENZOATE