ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Piperazine compounds > Dropropizine
Dropropizine
Dropropizine Basic information
- Product Name:
- Dropropizine
- Synonyms:
-
- 3-(4-phenyl-1-piperazinyl)-2-propanediol
- catabex
- dipropizine
- ditustat
- dopropizin
- katril
- larylin
- 1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL)-
- CAS:
- 17692-31-8
- MF:
- C13H20N2O2
- MW:
- 236.31
- EINECS:
- 241-683-7
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 17692-31-8.mol
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Dropropizine Chemical Properties
- Melting point:
- 105° (Morren); mp 108° (Bourdais)
- Boiling point:
- 205 °C(Press: 1 Torr)
- Density
- 1.168±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- 14.21±0.20(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 17692-31-8(CAS DataBase Reference)
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MSDS
- Language:English Provider:3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
- Language:English Provider:SigmaAldrich
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Dropropizine Usage And Synthesis
Originator
Ribex,Formenti
Uses
antitussive
Uses
Dropropizine is a cough suppressant and central sedative therapeutic agent.
Definition
ChEBI: 3-(4-phenyl-1-piperazinyl)propane-1,2-diol is a member of piperazines.
Manufacturing Process
34 g 1,2-epoxy-3-hydroxypropane (glycide) in 50 ml of water were added to 64.8 g 1-phenylpiperazine in 80 ml of ethanol at the temperature not higher 50°C. The mixture was stood at night, then it was evaporated to dryness in vacuum and the stark product was recrystallized from 100 ml of acetone to give 60 g 1-phenyl-4-(2,3-dihydroxypropyl)piperazine (dropropizine) MP 105°C; BP 205°C/1 mm Hg.
Therapeutic Function
Antitussive
Dropropizine Preparation Products And Raw materials
Raw materials
DropropizineSupplier
Shanghai YuanYe Biotechnology Co., Ltd. Gold
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel
- 4006608290; 18621169109
- market03@meryer.com
Energy Chemical
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
- Tel
- 0311-89250318 031166536426
- master@sjzsdyn.com
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Dropropizine(17692-31-8)Related Product Information
- PHENYL VALERATE
- 1-Methoxy-2-propyl acetate
- Hydroxypropyl methyl cellulose
- 2-Hydroxypropyl-β-cyclodextrin
- trans-1-Cinnamylpiperazine
- Diphenyl ether
- (R)-(-)-1,2-Propanediol
- Diprophylline
- 1-Methoxy-2-propanol
- Propylene glycol
- 1,3-Propanediol
- Poly(propylene glycol)
- Hydroxypropyl cellulose
- Hydroxypropyl acrylate
- PHENYL RESIN
- (S)-Dropropizine
- mociprazine
- Centpropazine